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 Friday, May 1, 2009
12:00 p.m.   Other Tri-Institutional Events
A Developmental Perspective on Brain Cancer

David Rowitch, M.D., Ph.D., professor of pediatrics and neurological surgery, Children's Hospital, University of California, San Francisco Medical Center; chief of neonatology, Institute for Regeneration Medicine; investigator, Howard Hughes Medical Institute

 Monday, May 4, 2009
12:00 p.m.   Thesis Presentations
Regulated Histone H3 Proteolysis: A Mechanism for Regulating the Stem Cell Epigenome?

Elizabeth Duncan, graduate fellow, Rockefeller University

1:30 p.m.   Other Tri-Institutional Events
Regulation of ESX-1 Secretion in Mycobacterium tuberculosis

Jeffery Cox, Ph.D., associate professor, department of microbiology and immunology, University of California, San Francisco

7:00 p.m.   Club Meetings
Improvisational Theater Group
 Tuesday, May 5, 2009
4:00 p.m.   Center for Studies in Physics and Biology Seminars
Predictive Pattern Detection in the Retina

Michael Berry, Ph.D., associate professor, Princeton University

 Wednesday, May 6, 2009
12:00 p.m.   Seminars in Clinical Research
Bioenergetics of Regulation of Body Weight

Rudolph Leibel, M.D., professor, department of pediatrics and molecular genetics, Columbia University

5:00 p.m.   Other Tri-Institutional Events
The Greene Sickness and Clinical Fantasy
Heberden Society Lecture

Charles L. Bardes, M.D., professor of clinical medicine, Weill Cornell Medical College

 Thursday, May 7, 2009
11:00 a.m.   Other Tri-Institutional Events
Millisecond-scale Molecular Dynamics Simulations of Proteins

David E. Shaw, Ph.D., chief scientist, D.E. Shaw Research; senior research fellow, Center for Computational Biology and Bioinformatics, Columbia University

2:00 p.m.   Thesis Presentations
Transcriptional Regulation of Fat Cell Development and Function

Kivanc Birsoy, graduate fellow, Rockefeller University

3:30 p.m.   Thesis Presentations
The Lassoed Tail of Microcin and Other Stories

Kelly-Anne Twist, graduate fellow, Rockefeller University

 Friday, May 8, 2009
12:00 p.m.   Other Tri-Institutional Events
"Classical" End Joining: Better by Design

Dale Ramsden, Ph.D., associate professor, department of biochemistry and biophysics, University of North Carolina, Chapel Hill

 Monday, May 11, 2009
2:00 p.m.   Center for Studies in Physics and Biology Seminars
Universality and Geometry

Misha Lyubich, Ph.D., professor, Stony Brook University

Yair Minsky, Ph.D., professor, Yale University

Folkert Tangerman, Ph.D., research assistant professor, Stony Brook University

7:00 p.m.   Club Meetings
Improvisational Theater Group
 Tuesday, May 12, 2009
4:00 p.m.   Center for Studies in Physics and Biology Seminars
A Systems-level Analysis of Spore Coat Assembly in Bacillus subtilis

Patrick Eichenberger, Ph.D., assistant professor, New York University

6:45 p.m.   Other Seminars
Diplomacy with Iran Is Going Nowhere

Intelligence Squared U.S. Debate
 Wednesday, May 13, 2009
12:00 p.m.   Seminars in Clinical Research
Population-based Interventions: Bringing Science to Healthy Aging

Linda Fried, M.D., dean, Mailman School of Public Health, Columbia University

4:30 p.m.   MSKCC President's Research Seminar
Stem Cells and Early Development

Janet Rossant, M.D., FRS, FRSC, senior scientist and chief of research, Toronto Hospital for Sick Children

 Thursday, May 14, 2009
11:00 a.m.   Other Tri-Institutional Events
Analysing Vertebrate Genomes: From Annotation to Machine Learning

Tim Hubbard, Ph.D., head of informatics and member, board of management, Wellcome Trust Sanger Institute

12:00 p.m.   Biochemistry Lectures
Worming Out Causes and Cures to Movement Disorders

Guy A. Caldwell, Ph.D., associate professor, department of biological sciences, University of Alabama

2:00 p.m.   Other Tri-Institutional Events
How Stem Cells Find Their Niche: Germ Cell Migration in Vivo

Ruth Lehmann, Ph.D., director and Laura and Isaac Perlmutter Professor of Cell Biology, Skirball Institute for Biomedical Research, New York University School of Medicine; investigator, Howard Hughes Medical Institute

 Monday, May 18, 2009
10:00 a.m.   Other Tri-Institutional Events
Alvin Freiman Memorial
1:30 p.m.   Other Tri-Institutional Events
RNA Interference Genetic Screens Reveal the Regulatory Biology of Normal and Malignant Lymphocytes

Louis M. Staudt, M.D., Ph.D., chief, Lymphoid Malignancies Section, National Institutes of Health

7:00 p.m.   Club Meetings
Improvisational Theater Group
 Tuesday, May 19, 2009
4:00 p.m.   Center for Studies in Physics and Biology Seminars
Singing in the Brain: Neurobiology of Vocal Learning in Songbirds

Bence Olveczky, Ph.D., assistant professor, Harvard University

 Wednesday, May 20, 2009
12:00 p.m.   Seminars in Clinical Research
Community Partnerships for Translational Research

Daniel S. Blumenthal, M.D., MPH, professor and chair, department of community health and preventive medicine, Morehouse School of Medicine

4:30 p.m.   MSKCC President's Research Seminar
New Concepts on the Regulation of Tumor Development and Metastasis

Zena Werb, Ph.D., professor and vice chair, department of anatomy, University of California, San Francisco

6:00 p.m.   The Peggy Rockefeller Concerts
Peggy Rockefeller Buffet Dinner
8:00 p.m.   The Peggy Rockefeller Concerts
Guarneri String Quartet

Performing works by Ludwig van Beethoven
Guarneri String Quartet
 Thursday, May 21, 2009
2:00 p.m.   Other Tri-Institutional Events
Stem Cell Renewal and Lineage Selection in Mammalian Epidermis

Fiona Watt, Ph.D., deputy director, CRUK, Cambridge Research Institute, deputy director, Wellcome Trust Centre for Stem Cell Research, Herchel Smith Professor of Molecular Genetics, University of Cambridge

4:30 p.m.   Other Tri-Institutional Events
Signaling and Cell Cycle Regulation in Brain Development and Pediatric Brain Tumors

Anna Kenney, Ph.D., Assistant Member, Cell Biology & Genetics program, MSKCC

 Friday, May 22, 2009
12:00 p.m.   Other Tri-Institutional Events
Systems Biology of the Mitotic Oscillator

James E. Ferrell Jr., M.D., Ph.D., professor and chair of chemical and systems biology and professor of biochemistry, Stanford University

2:00 p.m.   Center for Studies in Physics and Biology Seminars
Bacterial Persistence: Causes and Consequences

Natalie Balaban, Ph.D., senior lecturer, Hebrew University

 Monday, May 25, 2009
7:00 p.m.   Club Meetings
Improvisational Theater Group
 Tuesday, May 26, 2009
7:00 p.m.   Other Special Events
Psoriasis Support Group
 Wednesday, May 27, 2009
11:00 a.m.   Other Tri-Institutional Events
Expanding Our Window on Genetic Variation

Richard McCombie, Ph.D., professor, Cold Spring Harbor Laboratory

12:00 p.m.   Seminars in Clinical Research
Our Gut Microbiota and Microbiome: Dining In with a Few Trillion Friends

Jeffrey Gordon, M.D., director, Center for Genome Sciences, Washington University School of Medicine

 Thursday, May 28, 2009
9:00 a.m.   Other Tri-Institutional Events
Generating and Correcting Leading- and Lagging-strand DNA Replication Errors in Yeast: A Symposium on Genomic Integrity

Thomas Kunkel, Ph.D., principal investigator, DNA replication fidelity group, National Institutes of Health

10:00 a.m.   Other Tri-Institutional Events
How Do Helicases Know Which Way to Walk? A Symposium on Genomic Integrity

Dale Wigley, Ph.D., researcher, Molecular Enzymology Laboratory, Cancer Research UK

11:00 a.m.   Other Tri-Institutional Events
Molecular Dissection of the Tumor Microenvironment

Johanna Joyce, Ph.D., assistant member, Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center

11:00 a.m.   Other Tri-Institutional Events
Genetic Analysis of the the Eukaryotic DNA Damage Response: A Symposium on Genomic Integrity

John Petrini, Ph.D., member lab head, molecular biology, Sloan-Kettering Institute

11:30 a.m.   Other Tri-Institutional Events
Cellular Responses to DNA Double-strand Breaks: A Symposium on Genomic Integrity

Steve Jackson, Ph.D., Frederick James Quick Professor of Biology, University of Cambridge

12:00 p.m.   Other Tri-Institutional Events
A Novel Mechanism of Stringent Control in Mycobacteria in Response to Double-strand Breaks: A Symposium on Genomic Integrity

Michael Glickman, M.D., associate member and lab head, immunology program, Sloan-Kettering Institute

1:30 p.m.   Other Tri-Institutional Events
Timing and Spacing of Ubiquitin-dependent DNA Damage Bypass: A Symposium on Genomic Integrity

Helle Ulrich, Ph.D., researcher, DNA Damage Tolerance Laboratory, Cancer Research UK

2:00 p.m.   Other Tri-Institutional Events
The Smc5/6 Complex and Recombinational Repair: A Symposium on Genomic Integrity

Xiaolan Zhao, Ph.D., assistant member, molecular biology, Sloan-Kettering Institute

2:30 p.m.   Other Tri-Institutional Events
RNA Repair: A Symposium on Genomic Integrity

Stewart Shuman, Ph.D., member, molecular biology Program, Sloan-Kettering Institute

3:30 p.m.   Other Tri-Institutional Events
Connections between Transcription and DNA Integrity: A Symposium on Genomic Integrity

Jesper Svejstrup, Ph.D., researcher, Mechanisms of Gene Transcription Laboratory, Cancer Research UK

4:00 p.m.   Other Tri-Institutional Events
Small RNAs: Mediators of Gene Regulation and Silencing: A Symposium on Genomic Integrity

Dinshaw Patel, Ph.D., member and lab head, structural biology program, Sloan-Kettering Institute

4:30 p.m.   Other Tri-Institutional Events
Small Regulatory RNAs in Drosophila: A Symposium on Genomic Integrity

Eric Lai, Ph.D., assistant member and lab head, devleopmental biology program, Sloan-Kettering Institute

 Friday, May 29, 2009
10:00 a.m.   Other Tri-Institutional Events
Cell Division and Aneuploidy: A Symposium on Genomic Integrity

Mark Petronczki, Ph.D., researcher, Cell Division and Aneuploidy Laboratory, Cancer Research UK

10:30 a.m.   Other Tri-Institutional Events
Double-strand Break Repair and Genomic Integrity in Mammalian Cells: A Symposium on Genomic Integrity

Maria Jasin, Ph.D., member and lab head, developmental biology program, Sloan-Kettering Institute

11:30 a.m.   Other Tri-Institutional Events
Structure of the RecA-DNA Filament and the Mechanism of Recombination: A Symposium on Genomic Integrity

Nikola Pavletich, Ph.D., chair and lab head, structural biology program, Sloan-Kettering Institute

12:00 p.m.   Other Tri-Institutional Events
The Fbw7 Ubiquitin Ligase: A Tumor Suppressor That Degrades a Constellation of Oncogenes

Bruce Clurman, M.D., Ph.D., member, Fred Hutchinson Cancer Center; professor, University of Washington School of Medicine

12:00 p.m.   Other Tri-Institutional Events
Identification of Holliday Junction Resolvases from Yeast and Human Cells: A Symposium on Genomic Integrity

Stephen West, Ph.D., researcher, Genetic Recombination Laboratory, Cancer Research UK

1:30 p.m.   Other Tri-Institutional Events
Recognition of DNA Junctions by the XPF/Mus81 Family: A Symposium on Genomic Integrity

Neil McDonald, Ph.D., researcher, Structural Biology Laboratory, Cancer Research UK

2:00 p.m.   Other Tri-Institutional Events
Fine-scale Genome-wide Mapping of Sites of Meiotic Recombination Initiation: A Symposium on Genomic Integrity

Scott Keeney, Ph.D., member and lab head, molecular biology, Sloan-Kettering Institute

2:30 p.m.   Other Tri-Institutional Events
Controlling the Crossover/Non-crossover Ratio; Implications for Crossover Interference and Homeostasis: A Symposium on Genomic Integrity

Simon Boulton, Ph.D., Researcher, DNA Damage Response Laboratory, Cancer Research UK

3:30 p.m.   Other Tri-Institutional Events
Mechanism and Regulation of Pre-RC Assembly in Yeast: A Symposium on Genomic Integrity

John Diffley, Ph.D., researcher, Chromosome Replication Laboratory, Cancer Research UK

4:00 p.m.   Other Tri-Institutional Events
Genome Stability and the Eukaryotic Replisome: A Symposium on Genomic Integrity

Karim Labib, Ph.D., researcher, cell cycle group, Cancer Research UK

4:30 p.m.   Other Tri-Institutional Events
Coupling Cohesion Establishment and Replication Fork Progression through  Acetylation-dependent Eviction of Cohesin Regulators: A Symposium on Genomic Integrity

Prasad Jallepalli, M.D., Ph.D., associate member and lab head, molecular biology program, Sloan-Kettering Institute

 Monday, June 1, 2009
7:00 p.m.   Club Meetings
Improvisational Theater Group
 Wednesday, June 3, 2009
4:30 p.m.   MSKCC President's Research Seminar
Molecular Pathology of Acute Leukemia

James Downing, M.D., scientific director, St. Jude Children’s Research Hospital

 Thursday, June 4, 2009
9:00 a.m.   Other Seminars
A Celebratory Symposium Honoring Jürg Ott
Analysis of Human Genetic Data

Charles Cantor, Ph.D., chief science officer, Sequenom

Marcella Devoto, Ph.D., associate professor, Children’s Hospital of Philadelphia, Genomic Analysis of Neuroblastoma: Rare Mutations and Common Variants

Andrew DeWan, Ph.D., assistant professor, Yale University, Genetic Epidemiology of Human Complex Diseases: AMD and Asthma

Suzanne Leal, Ph.D., professor, Baylor College of Medicine, Statistical Methods for the Analysis of Complex Trait Association Studies of Rare Variants: Application to the Analysis of Sequence Data

Mark Lathrop, Ph.D., director, National Genotyping Center, France, From Linkage to Association: The Impact of Statistical Genetics in Medical Studies

Elizabeth Thompson, Ph.D., professor, University of Washington, The Structure of Genetic Data for Linkage Analysis: From LIPED to SNPs

Daniel Weeks, Ph.D., professor, University of Pittsburgh, Associated Genetic Variants and Personalized Medicine

11:00 a.m.   Other Tri-Institutional Events
Adaptive Prediction of Environmental Changes by Microorganisms

Yitzhak Pilpel, Ph.D., principal investigator, department of molecular genetics, Weizmann Institute of Science

1:30 p.m.   Other Tri-Institutional Events
Using Stem Cells and Reprogramming to Study the Developmental Biology of Disease: A Case Study in ALS

Kevin Eggan, Ph.D., assistant professor, department of stem cell and regenerative biology, Harvard University

 Friday, June 5, 2009
12:00 p.m.   Other Tri-Institutional Events
Structure and Function of Yeast and Human Translesion Synthesis DNA Polymerases

Satya Prakash, Ph.D., professor, department of biochemistry and molecular biology, University of Texas





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